A Non-inflammatory Role for Microglia in Autism Spectrum Disorders

A Non-inflammatory Role for Microglia in Autism Spectrum Disorders

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social interaction, difficulties with language, and repetitive/restricted behaviors. The etiology of ASD is still largely unclear, but immune dysfunction and abnormalities in synaptogenesis have repeatedly been implicated as contributing to the disease phenotype. However, an understanding of how and if ...

Microglia in the pathogenesis of autism spectrum disorders.

Proper synaptic pruning is essential for the development of functional neural circuits. Impairments in synaptic pruning disrupt the excitatory versus inhibitory balance (E/I balance) of synapses, which may cause neurodevelopmental disorders such as autism spectrum disorder (ASD). Recent studies have determined molecular mechanisms by which microglia, the brain's resident immune cells, engulf in...

Etiology of Sleep Disorders in ASD (Autism Spectrum Disorders): Role for Inflammatory Cytokines

autism spectrum disorders in iran

how to cite this article: mohammadi mr, salmanian m, akhondzadeh sh. autism spectrum disorders in iran. iranian journal of child neurology2011;5(4):1-9. objective autistic disorder, asperger syndrome, and pdd-not otherwise specified are subsets of autism spectrum disorders (asds), which are characterized by impairments in social communication and stereotyped behavior. this article reviews the p...

Economic burden of autism spectrum disorders in Iran

Background: The prevalence of autism spectrum disorder (ASD) as a child neurodevelopmental disorder has increased significantly during the past 3 decades worldwide and in Iran. This chronic disease does not cause premature death and there is no definitive treatment. Thus, the cost of ASD is extremely heavy and overwhelming. The purpose of this study is to calculate the economic burden of ASD in...